[HTML][HTML] C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia
W Posch, J Vosper, A Noureen, V Zaderer… - Journal of Allergy and …, 2021 - Elsevier
Background Excessive inflammation triggered by a hitherto undescribed mechanism is a
hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and
is associated with enhanced pathogenicity and mortality. Objective Complement
hyperactivation promotes lung injury and was observed in patients suffering from Middle
East respiratory syndrome-related coronavirus, SARS-CoV-1, and SARS-CoV-2 infections.
Therefore, we investigated the very first interactions of primary human airway epithelial cells …
hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and
is associated with enhanced pathogenicity and mortality. Objective Complement
hyperactivation promotes lung injury and was observed in patients suffering from Middle
East respiratory syndrome-related coronavirus, SARS-CoV-1, and SARS-CoV-2 infections.
Therefore, we investigated the very first interactions of primary human airway epithelial cells …