[HTML][HTML] c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
Activation of the c-Jun N-terminal kinase (JNK) by proinflammatory cytokines inhibits insulin
signaling, at least in part, by stimulating phosphorylation of rat/mouse insulin receptor
substrate 1 (Irs1) at Ser 307 (Ser 312 in human IRS1). Here we show that JNK mediated
feedback inhibition of the insulin signal in mouse embryo fibroblasts, 3T3-L1 adipocytes,
and 32D IR cells. Insulin stimulation of JNK activity required phosphatidylinositol 3-kinase
and Grb2 signaling. Moreover, activation of JNK by insulin was inhibited by a cell-permeable …
signaling, at least in part, by stimulating phosphorylation of rat/mouse insulin receptor
substrate 1 (Irs1) at Ser 307 (Ser 312 in human IRS1). Here we show that JNK mediated
feedback inhibition of the insulin signal in mouse embryo fibroblasts, 3T3-L1 adipocytes,
and 32D IR cells. Insulin stimulation of JNK activity required phosphatidylinositol 3-kinase
and Grb2 signaling. Moreover, activation of JNK by insulin was inhibited by a cell-permeable …