[HTML][HTML] Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease
R Abskharon, PM Seidler, MR Sawaya… - Journal of Biological …, 2020 - ASBMB
Soluble oligomers of aggregated tau accompany the accumulation of insoluble amyloid
fibrils, a histological hallmark of Alzheimer disease (AD) and two dozen related
neurodegenerative diseases. Both oligomers and fibrils seed the spread of Tau pathology,
and by virtue of their low molecular weight and relative solubility, oligomers may be
particularly pernicious seeds. Here, we report the formation of in vitro tau oligomers formed
by an ionic liquid (IL15). Using IL15-induced recombinant tau oligomers and a dot blot …
fibrils, a histological hallmark of Alzheimer disease (AD) and two dozen related
neurodegenerative diseases. Both oligomers and fibrils seed the spread of Tau pathology,
and by virtue of their low molecular weight and relative solubility, oligomers may be
particularly pernicious seeds. Here, we report the formation of in vitro tau oligomers formed
by an ionic liquid (IL15). Using IL15-induced recombinant tau oligomers and a dot blot …