Importance Intracellular tau protein aggregates are a pathological hallmark of
neurodegenerative tauopathies, including Alzheimer disease (AD), progressive
supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick disease. Emerging
evidence supports a model of cell-to-cell transmission of proteinaceous pathological tau
seeds, which leads to recruitment and templated fibrillization of endogenous cellular tau
followed by the spread of abnormal tau throughout the brain. These findings lead to the …