[HTML][HTML] Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils
Membraneless organelles (MLOs) are vital and dynamic reaction centers in cells that
compartmentalize the cytoplasm in the absence of a membrane. Multivalent interactions
between protein low-complexity domains contribute to MLO organization. Previously, we
used computational methods to identify structural motifs termed low-complexity amyloid-like
reversible kinked segments (LARKS) that promote phase transition to form hydrogels and
that are common in human proteins that participate in MLOs. Here, we searched for LARKS …
compartmentalize the cytoplasm in the absence of a membrane. Multivalent interactions
between protein low-complexity domains contribute to MLO organization. Previously, we
used computational methods to identify structural motifs termed low-complexity amyloid-like
reversible kinked segments (LARKS) that promote phase transition to form hydrogels and
that are common in human proteins that participate in MLOs. Here, we searched for LARKS …