The ubiquitin-proteasome system is the major pathway for the maintenance of protein
homeostasis. Its inhibition causes accumulation of ubiquitinated proteins; this accumulation
has been associated with several of the most common neurodegenerative diseases. Several
genetic factors have been identified for most neurodegenerative diseases, however, most
cases are considered idiopathic, thus making the study of the mechanisms of protein
accumulation a relevant field of research. It is often mentioned that the biggest risk factor for …