Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury
JC Mossanen, O Krenkel, C Ergen, O Govaere… - Hepatology, 2016 - journals.lww.com
Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure
(ALF) in humans and induces hepatocyte necrosis, followed by activation of the innate
immune system, further aggravating liver injury. The role of infiltrating monocytes during the
early phase of ALF is still ambiguous. Upon experimental APAP overdose in mice, monocyte‐
derived macrophages (MoMFs) massively accumulated in injured liver within 12‐24 hours,
whereas the number of tissue‐resident macrophages (Kupffer cells) decreased. Influx of …
(ALF) in humans and induces hepatocyte necrosis, followed by activation of the innate
immune system, further aggravating liver injury. The role of infiltrating monocytes during the
early phase of ALF is still ambiguous. Upon experimental APAP overdose in mice, monocyte‐
derived macrophages (MoMFs) massively accumulated in injured liver within 12‐24 hours,
whereas the number of tissue‐resident macrophages (Kupffer cells) decreased. Influx of …