A randomized, double-blind, placebo-controlled study of pulsed, inhaled nitric oxide in subjects at risk of pulmonary hypertension associated with pulmonary fibrosis
SD Nathan, KR Flaherty, MK Glassberg, G Raghu… - Chest, 2020 - Elsevier
Background The interstitial lung diseases include a variety of disorders, many of which are
characterized by fibrotic changes (fILD). Of the fILDs, Idiopathic pulmonary fibrosis is the
most common. Pulmonary hypertension (PH) frequently complicates fILD and is associated
with impaired functional capability, lower physical activity, and significantly reduced life
expectancy. There is no proven treatment for patients with fILD-PH. We report results from
the first cohort of a phase 2b/3 trial with pulsed inhaled nitric oxide (iNO) in patients with fILD …
characterized by fibrotic changes (fILD). Of the fILDs, Idiopathic pulmonary fibrosis is the
most common. Pulmonary hypertension (PH) frequently complicates fILD and is associated
with impaired functional capability, lower physical activity, and significantly reduced life
expectancy. There is no proven treatment for patients with fILD-PH. We report results from
the first cohort of a phase 2b/3 trial with pulsed inhaled nitric oxide (iNO) in patients with fILD …
