Targeting the TLR4/NF-κB pathway in β-amyloid-stimulated microglial cells: A possible mechanism that oxysophoridine exerts anti-oxidative and anti-inflammatory …
R Chen, Z Wang, Z Zhi, J Tian, Y Zhao, J Sun - Brain Research Bulletin, 2021 - Elsevier
Abstract β-amyloid (Aβ) accumulation is a major neuropathological characteristic of
Alzheimer's disease (AD) and serves as an inflammatory stimulus for microglial cells.
Oxysophoridine has multiple pharmacological effects, including anti-inflammatory and anti-
oxidative activities. In view of this, the current study aimed to investigate the effects of
oxysophoridine on Aβ-induced activation of microglial BV-2 cells. Cell Counting Kit-8 assay
showed that oxysophoridine concentration-dependently attenuated Aβ-induced viability …
Alzheimer's disease (AD) and serves as an inflammatory stimulus for microglial cells.
Oxysophoridine has multiple pharmacological effects, including anti-inflammatory and anti-
oxidative activities. In view of this, the current study aimed to investigate the effects of
oxysophoridine on Aβ-induced activation of microglial BV-2 cells. Cell Counting Kit-8 assay
showed that oxysophoridine concentration-dependently attenuated Aβ-induced viability …