[HTML][HTML] Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells
A Dastur, S Beaudenon, M Kelley, RM Krug… - Journal of Biological …, 2006 - ASBMB
ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein that is conjugated to cellular
proteins during innate immune responses to viral and bacterial infections. A recent
proteomics study identified 158 human proteins targeted for ISG15 conjugation, including
the ISG15 E1 and E2 enzymes (Ube1L and UbcH8, respectively) and a HECT E3 enzyme,
Herc5. Like the genes encoding Ube1L and UbcH8, expression of Herc5 was also induced
by IFN-β, suggesting that Herc5 might be a component of the ISG15 conjugation system …
proteins during innate immune responses to viral and bacterial infections. A recent
proteomics study identified 158 human proteins targeted for ISG15 conjugation, including
the ISG15 E1 and E2 enzymes (Ube1L and UbcH8, respectively) and a HECT E3 enzyme,
Herc5. Like the genes encoding Ube1L and UbcH8, expression of Herc5 was also induced
by IFN-β, suggesting that Herc5 might be a component of the ISG15 conjugation system …