[HTML][HTML] ISG15 secretion exacerbates inflammation in SARS-CoV-2 infection
X Cao - Nature immunology, 2021 - nature.com
X Cao
Nature immunology, 2021•nature.comConjugation of the ubiquitin-like protein ISG15 to targets (ISGylation) benefits antiviral
defense. However, SARS-CoV-2 induces human macrophages to preferentially secrete
ISG15 via its papain-like protease, and extracellular non-conjugated ISG15 acts as a
cytokine to exacerbate SARS-CoV-2-triggered inflammation.
defense. However, SARS-CoV-2 induces human macrophages to preferentially secrete
ISG15 via its papain-like protease, and extracellular non-conjugated ISG15 acts as a
cytokine to exacerbate SARS-CoV-2-triggered inflammation.
Conjugation of the ubiquitin-like protein ISG15 to targets (ISGylation) benefits antiviral defense. However, SARS-CoV-2 induces human macrophages to preferentially secrete ISG15 via its papain-like protease, and extracellular non-conjugated ISG15 acts as a cytokine to exacerbate SARS-CoV-2-triggered inflammation.
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