Background Granuloma annulare (GA) is a common cutaneous inflammatory disorder
characterized by macrophage accumulation and activation in skin. Its pathogenesis is poorly
understood, and there are no effective treatments. The potential health implications of
severe GA are unknown. Objective We sought to better understand GA pathogenesis and
evaluate a molecularly targeted treatment approach for this disease. Methods We used
single-cell RNA sequencing to study the immunopathogenesis of GA and also evaluated the …