Human leukocyte antigen-A,-B, and-DRB1 alleles and sarcoidosis in Chinese Han subjects
Y Zhou, L Shen, Y Zhang, D Jiang, H Li - Human immunology, 2011 - Elsevier
Human leukocyte antigens (HLA) play a key role in antigen presentation. HLA genes,
especially HLA-A,-B, and-DRB1, which are highly polymorphic, have been thought to be
candidate loci for the etiology of sarcoidosis. This study aimed to assess the association
between the polymorphism of HLA-A,-B, and-DRB1 alleles and sarcoidosis in Chinese Han
subjects. Genomic DNA was extracted from 131 patients with sarcoidosis and 122 healthy
controls. The polymorphisms of the HLA-A,-B, and-DRB1 alleles were determined using a …
especially HLA-A,-B, and-DRB1, which are highly polymorphic, have been thought to be
candidate loci for the etiology of sarcoidosis. This study aimed to assess the association
between the polymorphism of HLA-A,-B, and-DRB1 alleles and sarcoidosis in Chinese Han
subjects. Genomic DNA was extracted from 131 patients with sarcoidosis and 122 healthy
controls. The polymorphisms of the HLA-A,-B, and-DRB1 alleles were determined using a …
