[HTML][HTML] The Akt–mTOR network at the interface of hematopoietic stem cell homeostasis
F Wu, Z Chen, J Liu, Y Hou - Experimental hematology, 2021 - Elsevier
Highlights•The Akt–mTOR network governs HSC homeostasis.•Akt–mTOR signaling
regulates quiescence and metabolism in HSCs.•Akt–mTOR inhibitors are promising agents
in the clinic.Hematopoietic stem cells (HSCs) are immature blood cells that exhibit
multilineage differentiation capacity. Homeostasis is critical for HSC potential and lifelong
hematopoiesis, and HSC homeostasis is tightly governed by both intrinsic molecular
networks and microenvironmental signals. The evolutionarily conserved serine/threonine …
regulates quiescence and metabolism in HSCs.•Akt–mTOR inhibitors are promising agents
in the clinic.Hematopoietic stem cells (HSCs) are immature blood cells that exhibit
multilineage differentiation capacity. Homeostasis is critical for HSC potential and lifelong
hematopoiesis, and HSC homeostasis is tightly governed by both intrinsic molecular
networks and microenvironmental signals. The evolutionarily conserved serine/threonine …