[HTML][HTML] Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
D Stewart, E Killeen, R Naquin, S Alam… - Journal of Biological …, 2003 - ASBMB
Nrf2 mediates inducer-dependent activation of the heme oxygenase-1 (HO-1) gene (Alam,
J., Stewart, D., Touchard, C., Boinapally, S., Choi, AM, and Cook, JL (1999) J. Biol. Chem.
274, 26071–26078), but the mechanism by which HO-1 inducers regulate Nrf2 function is
not known. Treatment of mouse hepatoma (Hepa) cells with 50 μm CdCl 2 increased the
amount of Nrf2 protein in a time-dependent manner; induction was observed within 30 min,
prior to the accumulation of HO-1 mRNA. Cadmium did not significantly affect the steady …
J., Stewart, D., Touchard, C., Boinapally, S., Choi, AM, and Cook, JL (1999) J. Biol. Chem.
274, 26071–26078), but the mechanism by which HO-1 inducers regulate Nrf2 function is
not known. Treatment of mouse hepatoma (Hepa) cells with 50 μm CdCl 2 increased the
amount of Nrf2 protein in a time-dependent manner; induction was observed within 30 min,
prior to the accumulation of HO-1 mRNA. Cadmium did not significantly affect the steady …