Increased serum leucine, leucine-37 levels in psoriasis: positive and negative feedback loops of leucine, leucine-37 and pro-or anti-inflammatory cytokines
N Kanda, T Ishikawa, M Kamata, Y Tada… - Human immunology, 2010 - Elsevier
Expression of leucine, leucine-37 (LL-37) is enhanced in keratinocytes of skin lesions with
psoriasis. We examined serum LL-37 levels in patients with psoriasis vulgaris. Serum LL-37
levels in patients were higher than in normal controls, and were reduced after cyclosporine
A treatment. In both groups, LL-37 and interleukin (IL)–17 levels inversely correlated. In
patients, LL-37 levels correlated with interferon (IFN)–γ and IL-10 levels. In controls, LL-37
levels inversely correlated with tumor necrosis factor (TNF)–α, IL-6, IL-1β, and IL-22 levels …
psoriasis. We examined serum LL-37 levels in patients with psoriasis vulgaris. Serum LL-37
levels in patients were higher than in normal controls, and were reduced after cyclosporine
A treatment. In both groups, LL-37 and interleukin (IL)–17 levels inversely correlated. In
patients, LL-37 levels correlated with interferon (IFN)–γ and IL-10 levels. In controls, LL-37
levels inversely correlated with tumor necrosis factor (TNF)–α, IL-6, IL-1β, and IL-22 levels …